The outlook for children with 22q deletion syndrome (DiGeorge syndrome, VCFS) depends on the function of each affected organ system. The severity of heart disease is usually the most important determining factor. Most children have a mild to moderate deficit in T-cell production that often improves with age. Most patients do not have recurrent infections in adulthood.
Developmental delay, learning differences and problems with attention and behavior are common. Early childhood intervention, speech, occupational therapy and physical therapies can be very helpful.
Neurocognitive evaluation as children get older and in school can assist parents and teachers by providing recommendations for clinical management and academic support in the future.