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Pediatric Li-Fraumeni Syndrome (LFS)

Li-Fraumeni syndrome (LFS) is a condition that runs in families, causing high rates of cancer and cancer diagnosis at a young age.


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What is Pediatric Li-Fraumeni Syndrome (LFS)?

Li-Fraumeni syndrome (LFS) is a hereditary (runs in families) condition in which several people across multiple generations develop various types of cancer, and they are typically diagnosed at a young age (under 30).

A person may be diagnosed with LFS when all of the following are true:

  • Develops a sarcoma (rare cancer that grows in connective tissue) before age 45
  • Has a first-degree relative (parent, sibling or child) who is diagnosed with any cancer before age 45
  • Has a first- or second-degree (grandparent, aunt, uncle, niece, nephew or grandchild) who is diagnosed with any cancer before age 45 or with a sarcoma at any age

The most common types of cancers found in families with LFS are:

What are the signs and symptoms of Pediatric Li-Fraumeni Syndrome (LFS)?

Since LFS is a condition that increases the chance of cancer, children with this conditions should watch for signs of cancer, such as:

What are the causes of Pediatric Li-Fraumeni Syndrome (LFS)?

LFS is caused by a gene mutation that is hereditary (passed down within families).

Pediatric Li-Fraumeni Syndrome (LFS) Doctors and Providers