Pediatric Crohn's Disease

Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract and has been recognized as a significant disease in children and adolescents. It’s a form of inflammatory bowel disease (IBD).

What is Pediatric Crohn's Disease?

Crohn’s disease is a lifelong IBD involving intestinal segments of the digestive system. In a child with Crohn's disease, the immune system attacks healthy tissue in the digestive tract. The tissue becomes swollen and inflamed, causing the intestine walls to thicken.

The digestive system goes from the mouth to the anus, and Crohn's disease can affect any part of it, including the esophagus (the tube connecting the mouth and stomach), stomach and rectum, as well as both the small and large intestines. Crohn's disease most frequently occurs at the end of the small intestine and the beginning of the large intestine.

Children and young adults are most commonly diagnosed with Crohn's disease between the ages of 15 and 25 but, it can occur at any age.

What are the signs and symptoms of Pediatric Crohn's Disease?

Signs and symptoms of Crohn's disease include cramping or pain in the abdomen, fatigue, fever, lack of appetite, the need to pass stool even when bowels are empty, watery or bloody diarrhea and weight loss.

Symptoms during a flare-up may include:

How is Pediatric Crohn's Disease diagnosed?

Crohn's disease is diagnosed by:

  • Blood work and stool studies
  • X-ray: A single-contrast upper GI radiologic series
  • Magnetic resonance enterography (MRE)
  • MRI
  • Abdominal ultrasonography
  • Video capsule endoscopy
  • Endoscopy, including a colonoscopy with biopsy, upper endoscopy, or esophagogastroduodenoscopy (EGD)

Medical treatment aims to control the inflammatory progress of the disease, while minimizing any potential side effects caused by medications. Goals are to allow normal physical development and to provide as near a normal lifestyle as possible for the patient.

What are the causes of Pediatric Crohn's Disease?

Genetics and environmental factors can all have a role in the diagnosis of Crohn's disease. However, the exact cause of Crohn's disease remains unproven but it is understood to be a disorder of the immune system. Viral or bacterial agents are suspected as being possible triggers behind the response.

How is Pediatric Crohn's Disease treated?

Medical Treatments Include

  • Biologic agents
  • Antibiotic therapy
  • Corticosteroid therapy
  • Oral immunomodulators
  • Dietary therapy


Patients might require surgery if they fail to respond to medical treatment or do not thrive. Surgery is effective, but not curative, and flare ups of the disease will likely recur.

Many Crohn’s disease patients need to have only portions of their colon and small intestine removed. Strictureplasty is a technique that lets a surgeon widen a portion of the small intestine that has become narrow due to the damage and scarring caused by Crohn’s disease. Our surgeons also offer surgical treatment for complications of Crohn’s disease, such as abscesses and fistulas.

Minimally invasive laparoscopic surgery can be performed in many cases. At Children’s Health℠, the most advanced surgical techniques, such as minimally invasive surgery, are used to treat this disorder. Such techniques result in less pain and scarring for your child.

Pediatric Crohn's Disease Doctors and Providers