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$$ Edaire Cheng, MD Assistant Professor at UT Southwestern Medical Center

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UTSW Physician Practicing at Children's Health


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Board Certification American Board of Pediatrics/Gastroenterology
Languages Spoken: English
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Biography

Biography

Edaire Cheng, M.D., is a gastroenterologist at Children’s Health℠ who specializes in eosinophilic esophagitis. She is also an assistant professor of pediatrics and internal medicine at UT Southwestern Medical Center.

Dr. Cheng received her medical degree from UT Southwestern, where she also completed her internship and residency in pediatric medicine and her fellowship in pediatric gastroenterology, hepatology and nutrition.

Dr. Cheng’s clinical interests include eosinophilic esophagitis, gastroesophageal reflux disease and eosinophilic gastrointestinal disease.

Her research interests include understanding mechanisms of eosinophilic infiltration, allergy-mediated inflammation and tissue remodeling of the esophagus.

Dr. Cheng is co-director of the Eosinophilic Gastrointestinal Diseases Program, a multidisciplinary team dedicated to patients affected with eosinophilic disorders of the GI tract and their families.  She is also the pediatric team leader of the Esophageal Diseases Center, which is devoted to conducting innovative, translational research in a multidisciplinary setting in order to advance understanding of esophageal diseases, and to improve the treatment of patients with those diseases. 

Education and Training

Education and Training

Medical School

University of Texas Southwestern Medical Center (2005)

Residency

UT Southwestern - Children's Medical Center (2008), Pediatrics

Fellowship

UT Southwestern - Children's Medical Center (2011), Pediatric Gastroenterology
Conditions & Treatments

Conditions & Treatments

Conditions

Treatments

Research & Publications

Research & Publications

Research Interests

  • Zhang HY, Zhang X, Yu C, Huo X, Cheng E, Wang DH, Zhang Q, Spechler SJ, Souza RF. Cancer-Related Inflammation and Barrett’s Carcinogenesis: Interleukin-6 and STAT3 Mediate Apoptotic Resistance in Transformed Barrett’s Cells. American Journal of Physiology Gastrointestinal and Liver Physiology, 300: G454-G460, 2011. PMID: 21148399 PMCID: PMC3064115
  • Huo X, Juergens S, Zhang X, Rezaei D, Yu C, Strauch ED, Wang J-Y, Cheng E, Meyer F, Wang DH, Zhang Q, Spechler SJ, Souza RF. Deoxycholic Acid Causes DNA Double Strand Breaks while Inducing Apoptotic Resistance through NF-kB Activation in Benign Barrett’s Epithelial Cells. American Journal of Physiology Gastrointestinal and Liver Physiology, 301: G278-G286, 2011. PMID: 21636532 PMCID: PMC3154602
  • Yu C, Zhang Q, Zhang HY, Zhang X, Huo X, Cheng E, Wang DH, Arbiser JL, Spechler SJ, Souza RF. Targeting the Intrinsic Inflammatory Pathway: Honokiol Exerts Pro-Apoptotic Effects through STAT3 Inhibition in Transformed Barrett’s Cells. American Journal of Physiology Gastrointestinal and Liver Physiology, 303: G561-9, 2012. PMID: 22744336 PMCID: PMC3468554
  • Zhang X, Cheng E, Huo X, Yu C, Zhang Q, Pham T, Wang DH, Spechler SJ, Souza RF. Omeprazole Blocks STAT6 Binding to the Eotaxin-3 Promoter in Eosinophilic Esophagitis Cells. Plos One, 7: e50037, 2012. PMID: 23185525 PMCID: PMC3503709
  • Cheng E, Zhang X, Huo X, Yu C, Zhang Q, Wang DH, Spechler SJ, Souza RF. Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD. Gut, 62: 824-832, 2013. PMID: 22580413 PMCID: PMC3552049
  • Zhang Q, Yu C, Peng S, Xu H, Wright E, Zhang X, Huo X, Cheng E, Pham TH, Asanuma K, Hatanpaa KJ, Rezai D, Wang DH, Sarode V, Melton S, Genta RM, Spechler SJ, Souza RF. Autocrine VEGF Signaling Promotes Proliferation of Neoplastic Barrett's Epithelial Cells Through a PLC-Dependent Pathway. Gastroenterology, 146: 461-472.e6, 2014. PMID: 24120473 PMCID: PMC3899829
  • Huo X, Zhang X, Yu C, Zhang Q, Cheng E, Wang DH, Pham TH, Spechler SJ, Souza RF. In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-κB and activator protein-1. Gut, 63: 1042-52, 2014. PMID: 24048734 PMCID: PMC3959621
  • Peng S, Huo X, Rezaei D, Zhang Q, Zhang X, Yu C, Asanuma K, Cheng E, Pham TH, Wang DH, Chen M, Souza RF, Spechler SJ. In Barrett’s esophagus patients and Barrett’s cell lines, ursodeoxycholic acid increases antioxidants expression and prevents DNA damage by bile acids. American Journal of Physiology Gastrointestinal and Liver Physiology, 307: G129-39, 2014. PMID: 24852569 PMCID: PMC4101678
  • Park J, Zhang X, Nguyen N, Souza RF, Spechler SJ, Cheng E. Proton Pump Inhibitors Decrease Eotaxin-3 Expression in the Proximal Esophagus of Children with Esophageal Eosinophilia. PLoS One, 9: e101391, 2014. PMID: 24988451 PMCID: PMC4079672
  • Asanuma K, Huo X, Agoston T, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham TH, Wang DH, Iijima K, Shimosegawa T, Odze RD, Spechler SJ, and Souza RF. In Oesophageal Squamous Cells, Nitric Oxide Causes S-Nitrosylation of Akt and Blocks SOX2 (Sex Determining Region Y-Box 2) Expression. Gut 2015. (Epub) PMID: 25986942 PMCID: PMC4651671
  • Yu C, Huo X, Agoston AT, Zhang X, Theiss AL, Cheng E, Zhang Q, Zaika A, Pham TH, Wang DH, Lobie PE, Odze RD, Spechler SJ, Souza RF. Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion. American Journal of Physiology Gastrointestinal and Liver Physiology 309:G146-61, 2015. PMID:26045618 PMCID: PMC4525109
  • Pezhouh MK, Cheng E, Weinberg AG, Park JY. Significance of Paneth Cells in Histologically
    Unremarkable Rectal Mucosa. American Journal of Surgical Pathology 40: 968-71, 2016. PMID: 26900817
  • Cheng E, Zhang X, Wilson KS, Wang DH, Park JY, HuoX, Yu C, Zhang Q, Spechler SJ, Souza RF. JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE. PLoS One 11:e0157376, 2016. PMID: 27310888 PMCID: PMC4911010

Selected Publications

  • Cheng E, Winter HS, Spechler SJ. “Relationship of Eosinophilic Esophagitis To Gastroesophageal Reflux”. Eosinophilic Esophagitis. Eds. Liacouras C, Markowitz J. New York: Springer, 2011.
  • Cheng E, Souza RF, Spechler SJ. Tissue Remodeling in Eosinophilic Esophagitis. American Journal of Physiology Gastrointestinal and Liver Physiology, 303: G1175-G1187, 2012. PMID: 23019192 PMCID: PMC3532456
  • Cheng E. Proton Pump Inhibitors for Eosinophilic Oesophagitis. Current Opinion in Gastroenterology, 29: 416-420, 2013. PMID: 23449027 PMCID: PMC4118554
  • Cheng E, Souza RF, Spechler  SJ. Eosinophilic Esophagitis: Interactions with Gastroesophageal Reflux Disease. Gastroenterology Clinics of North America 43: 243-56, 2014. PMID: 24813513 PMCID: PMC4019936  
  • Cheng E. Translating new developments in eosinophilic esophagitis pathogenesis into clinical practice. Current Treatment Options in Gastroenterology, 13: 30-46, 2015. PMID: 25598233 PMCID: PMC4329259
  • Molina-Infante J, Bredenoord AJ, Cheng E, Dellon ES, Furuta GT, Gupta SK, Hirano I, Katzka DA, Moawad FJ, Rothenberg ME, Schoepfer A, Spechler SJ, Wen T, Straumann A, Lucendo AJ. Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis. Gut 65:524-31, 2015. PMID: 26685124 PMCID: PMC4753110
  • Goyal A, Cheng E. Recent discoveries and emerging therapeutics in eosinophilic esophagitis. World Journal of Gastrointestinal Pharmacology and Therapeutics 7:21-31, 2016. PMID: 26855809

Professional Activities

Professional Activities

Professional Associations and Affiliations

Society

  • American Academy of Pediatrics, Member
  • North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition, Member
  • American Gastroenterological Association, Member
  • Gastroenterology Research Group, Member

Committees

  • North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition
  • Public Education Committee
  • North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition
  • Research Committee
  • American Gastroenterological Association Women’s Committee

Awards & Honors

Awards & Honors

  • Early Career Research Award, Children’s Health Children’s Clinical Research Advisory Committee (2016)
  • Research Scholar Award, American Gastroenterological Association (2013)
  • Award for Disorders of the Upper Gastrointestinal Tract, NASPGHAN Foundation/AstraZeneca (2012)
  • Distinguished Achievement Award, North American Conference of Gastroenterology Fellows (2011)
  • Felowship2Leadership Gastroenterology/ Hepatology, Fellowship2Leadership (2010)
  • Gastroenterology Research Group Fellows Travel Award, American Gastroenterological Association (2010)
  • Magna Cum Laude, Rice University (2001)