Pediatric Transverse Myelitis (TM)

What are the different types of Pediatric Transverse Myelitis?

There are different patterns of transverse myelitis that vary by what part of the spinal cord is affected, how large the affected area is, and what kind of damage it causes.

Upper motor neuron damage

This pattern of transverse myelitis affects tissue in the spinal cord called white matter. It can cause muscles to tighten after the initial period of weakness.

Lower motor neuron damage

This pattern of transverse myelitis affects the tissue in the spinal cord called gray matter. It can cause the affected limbs and muscles to be floppy rather than tight. This is the pattern seen in acute flaccid myelitis (AFM).

What are the signs and symptoms of Pediatric Transverse Myelitis?

TM usually involves muscle weakness or paralysis, and children usually have some problems urinating – a symptom that can appear early. In general, signs and symptoms include:

• Weakness
• Numbness (loss of sensation)
• Difficulty controlling bowel or bladder functions
• Inability to urinate or empty the bladder
• Difficulty walking
• Problems with balance

How is Pediatric Transverse Myelitis diagnosed?

The doctor will take a medical history and do a physical exam of your child. They may then do the following tests:

• MRI of the spinal cord, which can determine whether a child has acute flaccid myelitis or another condition.
• Testing of the spinal fluid for levels of white blood cells or other indicators of inflammation
• Testing of a nose (nasopharyngeal) swab, because the virus can be found in the nose and not in spinal fluid.
• Testing of stool specimens or rectal swabs to check for viral infections
• Blood tests to look for certain autoimmune conditions

The MRI is particularly important in determining whether a child has transverse myelitis or another condition.

What causes Pediatric Transverse Myelitis?

This neurological disorder can have three kinds of causes:

• Its causes may be unknown (this is called idiopathic). Most of these are believed to happen when the immune system causes damage after an infection.
• It may be caused by an autoimmune disorder. The most common autoimmune disorders that can trigger transverse myelitis in children are multiple sclerosis, neuromyelitis optica (which affects the spinal cord and eyes) and anti-MOG associated disorder (which attacks a particular type of protein).
• It may be triggered by an infection of the spinal cord. When the immune system responds to the infection, it triggers transverse myelitis. An example is acute flaccid myelitis, a very rare, polio-like condition.

How is Pediatric Transverse Myelitis treated?

If your child has transverse myelitis, we will first treat them to limit the inflammation in their spinal cord, such as with high doses of steroids. We may also use plasma exchange therapy, which replaces the plasma in the blood with other fluids. We may use intravenous immune globulin (IVIG), which is made up of blood proteins (antibodies) that help fight infections.

Next, we will work with them to manage their symptoms, which can mean helping manage nerve pain, problems with urinary or bowel function, or other complications.

Finally, we do rehabilitation to help with long-term care and recovery. Your child may benefit from physical therapy, to help them improve their coordination and strength. An occupational therapist can also work with your child if they need to learn new ways to do daily activities, such as bathing or getting dressed. It’s important to start these therapies early.