Pediatric Paget's Disease

Paget’s disease is a rare, genetic condition that affects bone formation – making them large, misshapen and fragile.

What is Pediatric Paget's Disease ?

Paget’s disease affects the way bone forms. In healthy bone formation, bone remodels every day as its absorbed and replaced by new bone. With Paget’s disease, more bone is absorbed than normal. The body tries to compensate, but makes too much bone that is abnormally large, deformed and very weak.

The whole skeleton is affected by Paget’s disease and can cause bone and joint pain throughout the body. Weak vertebrae can cause the spine to curve, and weight-bearing bones, such as the legs, can bow and break more easily.

Paget’s disease is rare, affecting only about 50 people worldwide.

What are the signs and symptoms of Pediatric Paget's Disease ?

Symptoms of Paget’s disease can appear in infancy or childhood. As children begin a growth spurt during adolescence (12-17 years of age), the symptoms can become more pronounced. These symptoms include:

What are the causes of Pediatric Paget's Disease ?

A genetic mutation causes Paget’s disease. A virus also may be responsible.