Todd Anthony Aguilera, MD $$

Radiation Oncologist

Assistant Professor at UT Southwestern Medical Center

Languages Spoken:
English,

Locations

UT Southwestern Pediatric Group

Education and Training

Medical School
University of California - San Diego (2011)
Internship
University of California - San Diego (2012), Internal Medicine
Residency
Stanford University (2016), Radiation Oncology
Fellowship
Stanford University Hospitals & Clinics (2017), Radiation Oncology
Board Certification
American Board of Radiology/Radiation Oncology

Departments and Programs

  • Research Interests

    • Radiation Therapy for Cancer
    • Radiation Therapy for Gastrointestinal Cancer
    • Radiation Therapy for Pancreatic Cancer
    • Rectal Cancer
    • Radiation Therapy for Colorectal Cancer
    • Radiation Therapy for Esophageal Cancer
    • Gastrointestinal Cancers
    • Radiation Therapy for Liver Cancer
    • Anal Cancer
    • Gallbladder/Bile Duct (Cholangiocarcinoma) Cancer
    • Radiation Therapy for Stomach Cancer
  • Publications

    • Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY Proceedings of the National Academy of Sciences of the United States of America 2010 Mar 107 9 4317-22
    • Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY Proceedings of the National Academy of Sciences of the United States of America 2010 Mar 107 9 4311-6
    • Fast 18F labeling of a near-infrared fluorophore enables positron emission tomography and optical imaging of sentinel lymph nodes. Ting R, Aguilera TA, Crisp JL, Hall DJ, Eckelman WC, Vera DR, Tsien RY Bioconjugate chemistry 2010 Oct 21 10 1811-9
    • A 3-D Riesz-Covariance Texture Model for Prediction of Nodule Recurrence in Lung CT. Cirujeda P, Dicente Cid Y, Muller H, Rubin D, Aguilera TA, Loo BW, Diehn M, Binefa X, Depeursinge A IEEE transactions on medical imaging 2016 Jul
    • 3D Riesz-wavelet based Covariance descriptors for texture classification of lung nodule tissue in CT. Cirujeda P, Muller H, Rubin D, Aguilera TA, Loo BW, Diehn M, Binefa X, Depeursinge A Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2015 2015 7909-12
    • In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Olson ES, Whitney MA, Friedman B, Aguilera TA, Crisp JL, Baik FM, Jiang T, Baird SM, Tsimikas S, Tsien RY, Nguyen QT Integrative biology : quantitative biosciences from nano to macro 2012 Jun 4 6 595-605
    • Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides. Whitney M, Crisp JL, Olson ES, Aguilera TA, Gross LA, Ellies LG, Tsien RY The Journal of biological chemistry 2010 Jul 285 29 22532-41
    • In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen QT, Wong EH, Gross LA, Tsien RY Integrative biology : quantitative biosciences from nano to macro 2009 Jun 1 5-6 382-93
    • Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome. Shu X, Royant A, Lin MZ, Aguilera TA, Lev-Ram V, Steinbach PA, Tsien RY Science (New York, N.Y.) 2009 May 324 5928 804-7
    • Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Aguilera TA, Olson ES, Timmers MM, Jiang T, Tsien RY Integrative biology : quantitative biosciences from nano to macro 2009 Jun 1 5-6 371-81
    • Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase. Aguilera TA, Giaccia AJ Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 23 12 2928-2933
    • Reprogramming the immunological microenvironment through radiation and targeting Axl. Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ Nature communications 2016 Dec 7 13898
    • Spiers Memorial Lecture. Breeding and building molecular spies. Shu X, Lev-Ram V, Olson ES, Aguilera TA, Jiang T, Whitney M, Crisp JL, Steinbach P, Deerinck T, Ellisman MH, Ellies LG, Nguyen QT, Tsien RY Faraday discussions 2011 149 9; discussion 63-77
    • Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Lin MZ, McKeown MR, Ng HL, Aguilera TA, Shaner NC, Campbell RE, Adams SR, Gross LA, Ma W, Alber T, Tsien RY Chemistry & biology 2009 Nov 16 11 1169-79
    • The end of the hypoxic EPOch. Aguilera TA, Giaccia AJ International journal of radiation oncology, biology, physics 2015 Apr 91 5 895-7
    • Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence Following Radiation Therapy in Immunosuppressed Patients. Rafat M, Aguilera TA, Vilalta M, Bronsart LL, Soto LA, von Eyben R, Golla MA, Ahrari Y, Melemenidis S, Afghahi A, Jenkins MJ, Kurian AW, Horst K, Giaccia AJ, Graves EE Cancer research 2018 Jun
    • Early-Stage Non-Small Cell Lung Cancer: Quantitative Imaging Characteristics of (18)F Fluorodeoxyglucose PET/CT Allow Prediction of Distant Metastasis. Wu J, Aguilera T, Shultz D, Gudur M, Rubin DL, Loo BW, Diehn M, Li R Radiology 2016 Apr 151829
    • Induced Tumor Heterogeneity Reveals Factors Informing Radiation and Immunotherapy Combinations. Aguilera TA, Elghonaimy EA, Shehade H, Rafat M, Castellini L, Jiang D, Kariolis M, Koong AC, Le QT, Ellies LG, Rankin EB, Graves EE, Giaccia AJ, Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Jun 26 12 2972-2985
    • Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia AJ Nature cell biology 2016 Sep 18 10 1078-1089
    • Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance. Nambiar DK, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, Wang Z, Rangan VS, Jiang D, von Eyben R, Liang R, Agarwal S, Colevas AD, Korman A, Allen CT, Uppaluri R, Koong AC, Giaccia A, Le QT, The Journal of clinical investigation 2019 Nov
    • The use of texture-based radiomics CT analysis to predict outcomes in early-stage non-small cell lung cancer treated with stereotactic ablative radiotherapy. Starkov P, Aguilera TA, Golden DI, Shultz DB, Trakul N, Maxim PG, Le QT, Loo BW, Diehn M, Depeursinge A, Rubin DL The British journal of radiology 2019 Feb 92 1094 20180228
    • Sociodemographic Disparities in the Receipt of Adjuvant Chemotherapy Among Patients With Resected Stage I-III Pancreatic Adenocarcinoma. Sanford NN, Aguilera TA, Folkert MR, Ahn C, Mahal BA, Zeh H, Beg MS, Mansour J, Sher DJ, Journal of the National Comprehensive Cancer Network : JNCCN 2019 Nov 17 11 1292-1300
    • A 3-D Riesz-Covariance Texture Model for Prediction of Nodule Recurrence in Lung CT. Cirujeda P, Dicente Cid Y, Muller H, Rubin D, Aguilera TA, Loo BW, Diehn M, Binefa X, Depeursinge A IEEE transactions on medical imaging 2016 Dec 35 12 2620-2630
  • Professional Activities

    • Society for Immunotherapy of Cancer (2015-2017)
    • American Society of Clinical Oncology (2013-2017)
    • America Association for Cancer Research (2012-2017)
    • Radiological Society of North America (2011-2017)
    • American Society for Radiation Oncology (2011-2017)
  • Awards and Honors

    • ASTRO Resident Seed Grant 2014-2015
    • American Board of Radiology Holman Research Resident 2014-2016
    • Malcom A. Bagshaw Symposium, Best Research Presentation 2015-2015
    • Henry S. Kaplan Fellow 2016-2017, Stanford Department or Radiation Oncology
    • Texas Monthly Super Doctors, Rising Star 2020