Pediatric Dose Optimization for Seizures in Emergency Medical Services (PediDOSE)
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Pediatric Dose Optimization for Seizures in Emergency Medical Services (PediDOSE)
Study ID: STU-2021-0713
Summary
The Pediatric Dose Optimization for Seizures in Emergency Medical Services (PediDOSE) study is an emergency medicine study designed to evaluate if a standardized method for paramedics to administer seizure medication leads to timely delivery of the right dose. The purpose of this study is to simplify how paramedics give medication to seizing children to stop the seizure and to decrease the number of children still seizing when they arrive at the emergency department. By replacing complicated dose calculations with age-based standardized dosing, we aim to increase the number of children who receive the right amount of seizure-stopping treatment before arriving at the hospital.
The primary objective of this study is to compare the impact of standardized EMS midazolam dosing on seizure cessation. We hypothesize that standardized intramuscular (IM) or intranasal (IN) midazolam dosing of approximately 0.2 mg/kg, based on age-based estimates for weight, will be associated with lower frequency of active seizures upon ED arrival, when compared to conventional dosing with calculations from estimated weights.