Ralph John DeBerardinis, MD Division Director at Children's Health Associate Professor at UT Southwestern Medical Center

Education and Training

Medical School

University of Pennsylvania School of Medicine (2000)

Residency

Children's Hospital of Philadelphia (2005), General Practice

Departments & Programs

Conditions & Treatments

Conditions

Treatments

Research & Publications

Research Interests

• Cancer
• Genetic disorders in children
• Inborn errors of metabolism
• Metabolism

Selected Publications

• Reductive carboxylation supports growth in tumour cells with defective mitochondria., Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, Deberardinis RJ Nature 2011 Nov
• Pyruvate carboxylase is required for glutamine-independent growth of tumor cells., Cheng T, Sudderth J, Yang C, Mullen AR, Jin ES, Matés JM, DeBerardinis RJ Proc. Natl. Acad. Sci. U.S.A. 2011 May 108 21 8674-9
• Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling., Yang C, Sudderth J, Dang T, Bachoo RM, Bachoo RG, McDonald JG, DeBerardinis RJ Cancer Res. 2009 Oct 69 20 7986-93
• The biology of cancer: metabolic reprogramming fuels cell growth and proliferation., DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB Cell Metab. 2008 Jan 7 1 11-20
• Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis., DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB Proc. Natl. Acad. Sci. U.S.A. 2007 Dec 104 49 19345-50

Professional Activities

Professional Associations and Affiliations

• American Society for Clinical Investigation (2013)
• American Academy of Pediatrics
• American Association for Cancer Research
• American Society of Human Genetics
• Society for Inherited Metabolic Disorders
• Society for Pediatrics Research

Awards & Honors

• Damon Runyon Cancer Research Foundation Clinical Investigator Award (2011)
• President’s Research Council Distinguished Young Researcher Award (2008)
• Soc. for Inherited Metabolic Disorders Neil Buist Award (2008)
• Sowell Family Scholar in Medical Research (2008)
• William K. Bowes, Jr. Award in Medical Genetics (2008)
• CHOP Pediatric Scholars Program & Faculty Honor Roll (2007)

Appointments & Locations

Request an Appointment with Ralph DeBerardinis online

Locations

Children’s Health℠ Specialty Center Dallas Campus