James S. Malter, MD Professor and Chair at UT Southwestern Medical Center

Biography

James Malter, M.D., is a pathologist at Children’s Health℠.

Dr. Malter earned his medical degree from Washington University School of Medicine in St. Louis. He then completed postdoctoral and residency training in pathology and laboratory medicine at the University of Pennsylvania.

“It’s the best patient care we can deliver when we bring together different doctors with different skill sets and expertise to provide the fastest, most up-to-date and most accurate diagnosis. That’s what everybody wants, and it’s a tremendous advantage to patients,” says Dr. Malter.

Dr. Malter has been continuously funded by the National Institutes of Health and other agencies since 1988. His research is currently supported by multiple individual and program project grants for his scientific work in post-transcriptional gene regulation and signaling in the immune and nervous systems.

Dr. Malter is a member of both the American Society for Investigative Pathology and the American Society for Clinical Investigation, past Chair of several NIH review panels and current member of the editorial boards of Journal of Experimental Medicine and Science Signaling.

Education and Training

Medical School

Washington University School of Medicine (1983)

Residency

University of Pennsylvania Medical Center (1988), Pathology

Departments & Programs

Research & Publications

Selected Publications

• Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines., Esnault S, Kelly EA, Johansson MW, Liu LY, Han ST, Akhtar M, Sandbo N, Mosher DF, Denlinger LC, Mathur SK, Malter JS, Jarjour NN Clin. Immunol. 2014 Jan 150 1 90-100
• Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours., Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF Nat Commun 2014 2 4802
• Pin1-FADD Interactions Regulate Fas-Mediated Apoptosis in Activated Eosinophils., Oh J, Malter JS J. Immunol. 2013 Apr
• Pin1 Null Mice Exhibit Low Bone Mass and Attenuation of BMP Signaling., Shen ZJ, Hu J, Ali A, Pastor J, Shiizaki K, Blank RD, Kuro-O M, Malter JS PLoS ONE 2013 8 5 e63565
• Identification of genes expressed by human airway eosinophils after an in vivo allergen challenge., Esnault S, Kelly EA, Schwantes EA, Liu LY, Delain LP, Hauer JA, Bochkov YA, Denlinger LC, Malter JS, Mathur SK, Jarjour NN PLoS ONE 2013 8 7 e67560

Professional Activities

Professional Associations and Affiliations

• American Association for the Advancement of Science
• American Association of Blood Banks
• American Society for Clinical Investigation
• American Society for Investigative Pathology
• American Society of Biochemistry and Molecular Biology

Awards & Honors

• Member - American Society for Clinical Investigation (1998)
• Nominee - Romnes Fellow, University of Wisconsin, Madison, WI (1993)
• Outstanding Young Investigator - Academy of Clinical Laboratory Physicians & Scientists (1987)
• NIH - National Research Service Award (1986)
• Rufus Choate Scholar - Biochemistry - Dartmouth College (1978)

Appointments & Locations