$$ Andrew Young Koh, MD Assistant Professor at UT Southwestern Medical Center
UTSW Physician Practicing at Children's Health
Andrew Koh, M.D., is the Director of Pediatric Hematopoeitic Stem Cell Transplantation at Children’s Health℠ and specializes in Pediatric Hematology/Oncology and Infectious Diseases. He is also an Assistant Professor of Pediatrics and Microbiology at UT Southwestern Medical Center.
After receiving his medical degree from Harvard Medical School, Dr. Koh completed a pediatrics residency at Children’s Hospital of Boston, where he also performed his Pediatric Infectious Diseases and Pediatric Hematology/Oncology fellowship training.
“As with most people who are drawn to medicine, I wanted to make a difference and help people,” Dr. Koh says. “To me, there is no greater opportunity to make a difference than to cure a child of a potentially fatal illness. It is a privilege and an honor.”
Dr. Koh researches how gut microbiota affect the development of infections and of graft-versus-host disease, a complication in which the transplanted immune system (the graft) attacks the patient recipient (the host).
In 2015, Dr. Koh was the senior author of an article in Nature Medicine showing how to reduce the presence of a fungus that causes infections and complications in cancer and stem cell transplantation (SCT) patients, decreasing mortality by 50 percent.
During medical school, Dr. Koh took two years off to pursue musical interests, something he still enjoys when he’s not working. Dr. Koh plays guitar and piano, sings, writes music and has a recording studio in his home.
Education and Training
Medical SchoolHarvard Medical School (1996)
ResidencyHarvard Medical School - Childrens Hospital (2000), Pediatrics
Harvard Medical School - Childrens Hospital (1999), Pediatrics
FellowshipHarvard Medical School - Childrens Hospital (2004), Pediatric Hematology/Oncology
Harvard Medical School - Childrens Hospital (2004), Pediatric Infectious Diseases
Conditions & Treatments
Research & Publications
- Candida albicans pathogenesis
- Host pathogen interactions
- Pseudomonas aeruginosa pathogenesis
- Candida albicans inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis. Lopez-Medina E, Fan D, Coughlin LA, Ho EX, Lamont IL, Reimmann C, Hooper LV, Koh AY. PLoS Pathogens 2015 Aug 27; 11(8):e1005129.
- Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization. Fan D, Coughlin LA, Neubauer MM, Kim J, Kim M, Zhan X, Simms-Waldrip TR, Xie Y, Hooper LV, Koh AY. Nature Medicine 2015 Jul; 21(7):808-14. doi:10.1038/nm.3871.
- Intravenous pentamidine is safe and effective as primary pneumocystis pneumonia prophylaxis in children and adolescents undergoing hematopoietic stem cell transplantation. Demasi JM, Cox JA, Leonard D, Koh AY, Aquino VM. Pediatr Infect Dis J. 2013 Mar 27.
- Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia. Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP. Journal of Infectious Diseases. 2013 Jan;207(1):39-49.
- Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination. Koh AY, Mikkelsen PJ, Smith RS, Coggshall KT, Kamei A, Givskov M, Lory S, Pier GB. PLoS ONE, 2010 Dec 10; 5(12): e15131.
- Mucosal damage and neutropenia are required for Candida albicans dissemination., Koh AY, Kohler JR, Coggshall KT, Van Rooijen N, Pier GB. PLoS Pathogens February 2008 4(2) e35
- A murine model of gastrointestinal colonization and dissemination during neutropenia for studying virulence of Pseudomonas aeruginosa., Koh AY, Priebe GP, Pier GB. Infection and Immunity 2005 73(4) 2262-2272
- Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination., Koh AY, Mikkelsen PJ, Smith RS, Coggshall KT, Kamei A, Givskov M, Lory S, Pier GB PLoS ONE December 2010 5(12) e15131
- Analysis of Acquisition of Pseudomonas aeruginosa Gastrointestinal Mucosal Colonization and Horizontal Transmission in a Murine Model., Kamei A*, Koh AY*, Gadjeva M, Priebe GP, Lory S, Pier GB (* Both authors contributed equally to this work) Journal of Infectious Diseases January 2010 201 (1) 71-80
- Inescapable need for Neutrophils as Mediators of Cellular Innate Immunity to Acute Pseudomonas aeruginosa Pneumonia, Koh AY, Priebe GP, Ray C, Van Rooijen N, Pier GB Infection and Immunity December 2009 77(12) 5300-5310
- Mucosal damage and neutropenia are required for Candida albicans dissemination, Koh AY, Kohler JR, Coggshall KT, Van Rooijen N, Pier GB PLoS Pathogens Spring 2008 4(2) e35
- A murine model of gastrointestinal colonization and dissemination during neutropenia for studying virulence of Pseudomonas aeruginosa, Koh AY, Priebe GP, Pier GB Infection and Immunity 2005 73(4) 2262-2272
Professional Associations and Affiliations
- American Society for Blood and Marrow Transplantation
- American Society for Microbiology
- American Society of Hematology
Awards & Honors
- Eleanor and Miles Shore Scholar (2006)
- Glaser Pediatric Research Network Fellowship Award (2000)
- Rhodes Scholarship (1988)