In the technologically sophisticated environment of pediatric intensive care, pediatric critical care specialists like Dr. Darryl Miles leverage a great deal of patience with specialized experience to make a difference at the bedside. They are crucial players in the collaborative effort to stabilize, diagnose and manage children with life-threatening conditions.
I am always looking for ways that we can improve the critical care management of patients and follow their recovery beyond the ICU.
Dr. Miles is focused on improving neurologic outcomes in pediatric patients following brain injuries and reducing neurologic complications of critical illness.
“I am inspired by the challenge of maximizing outcome potential in children that come in with an acute neurologic injury and improving their chances of recovery, as well as their long-term neurodevelopmental improvement,” he says.
Most critically ill or injured children have complex issues related to or in conjunction with their life-threatening neurologic condition. Dr. Miles, who is part of the Pediatric Neurocritical Care Research Group, is focused on improving the care of these patients through investigative research and a multidisciplinary team approach.
“I am always looking for ways that we can improve the critical care management of patients and follow their recovery beyond the ICU,” he says.
Dr. Miles is certified by the American Board of Pediatrics in pediatric critical care medicine. He earned his medical degree from the University of California at San Francisco, where he also completed an internship and residency in pediatrics. He completed a fellowship in pediatric critical care medicine at UT Southwestern.
He has participated in several NIH-sponsored multi-center clinical trials for therapies using systemic hypothermia to improve cognitive outcome after brain injury in children. In addition, he has also developed institutional practice guidelines for severe traumatic brain injury, status epilepticus and targeted temperature management. He is an assistant professor of pediatric critical care at UT Southwestern with research interests in traumatic brain injury in children.
Outside of his practice, Dr. Miles enjoys outdoor sports, particularly mountain and road biking.
Education and Training
- Medical School
- University of California San Francisco Sch of Med (1997)
- University of CA at San Francisco School of Med (1998), Pediatrics
- University of CA at San Francisco School of Med (2000), Pediatrics
- UT Southwestern Medical Center (HR) (2005), Critical Care Medicine
- Board Certification
- American Board of Pediatrics/Critical Care
- MRI imaging biomarkers of neuronal injury
- Neural stem cells
- Traumatic brain injury
- Hypoxic-ischemic brain injury activates early hippocampal stem/progenitor cells to replace vulnerable neuroblasts., Miles DK, Kernie SG Hippocampus 2008 18 8 793-806
- Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders., Miles DK, Freedman MH, Stephens K, Pallavicini M, Sievers EL, Weaver M, Grunberger T, Thompson P, Shannon KM Blood 1996 Dec 88 11 4314-20
- The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury., Chen Y, Miles DK, Hoang T, Shi J, Hurlock E, Kernie SG, Lu QR J. Neurosci. 2008 Oct 28 43 10983-9
- Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury., Koch JD, Miles DK, Gilley JA, Yang CP, Kernie SG J. Cereb. Blood Flow Metab. 2008 Jul 28 7 1294-306
- Pediatric Neurocritical Care Research Group (2009)
- Society of Critical Care Medicine
- Perot Center for Brain and Nerve Injury (2008-2014)
- National Neurotrauma Society
- Society of Neuroscience
Awards and Honors
- D Magazine Best Doctor 2022
- D Magazine Best Pediatric Specialist 2021
- Dean’s Prize for Research 1996, Presented by the University of California San Francisco
- Conferred Thesis Dissertation 1996, Presented by the University of California San Francisco
- Western Society of Pediatric Research Lowell Glasgow Award 1995, Presented by the University of California San Francisco
- Minority Access to Research Careers Fellowship 1993, San Jose State University
- Magna cum Laude 1993, San Jose State University