Optimizing Individual Nutrition in Preterm Very Low Birth Weight Infants: Randomized Clinical Trial
Study ID: STU 102014-056
The first specific aim will determine whether individualized and optimized nutrition during hospitalization improves growth in the niCu in eLGans and in SGa preterm infants [Less Than]35 weeks Ga compared with optimized nutrition. The second specific aim will determine whether individualized and optimized nutrition in the niCu improves neurodevelopment and reduces the risk of disproportionate growth (excess fat) in the niCu and findings suggestive of metabolic syndrome in the first 3 years of life. Hypotheses: 1. Primary hypothesis: in preterm infants (Ga [Less Than]29 weeks or Ga [Less Than]35 weeks and SGa) individualized and optimized nutrition will increase weight gain velocity from birth to 36 weeks of PMa by 2 g x kg-1 x day-1 and length velocity by 0.2 cm per week in comparison with optimized nutrition. 2. Secondary hypotheses: individualized and optimized nutrition will improve neurodevelopmental outcome and reduce the risk of disproportionate growth (excess fat) in the niCu and findings suggestive of metabolic syndrome in the first 3 years of life.
Patients born at Parkland Hospital & Health System Gestational age < 29 weeks or gestational age < 35 weeks and small for gestational age Maternal plan to breastfeed or to use milk from the milk donor bank From birth to 1 week (7 days) of life