APEC1621: NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)
Study ID: STU 072017-080
The Pediatric MaTCH (Molecular analysis for Therapy Choice) study, will match targeted agents with specific molecular changes identified using genomic sequencing technologies in refractory/recurrent tumors from children and adolescents with cancer. Pediatric MaTCH will employ an analytically validated next-generation sequencing targeted assay of more than 4,000 different mutations (SnVs, indels, copy number alterations, and gene fusions) across more than 140 genes. This assay will be coupled to a computer algorithm that uses pre-existing definitions and prioritization of target-agent pairs to assign patients by actionable mutation results to a targeted treatment.