Lennox-Gastaut Syndrome

Lennox-Gastaut Syndrome



Lennox-Gastaut syndrome is a rare, debilitating form of epilepsy that causes seizures, cognitive impairment and abnormal brain activity.

Expanded overview

Lennox-Gastaut syndrome is a rare and often debilitating type of epilepsy that usually first appears between the ages of 2 and 6. Due to its unique combination of symptoms, this condition is one of the most challenging forms of epilepsy to treat. What’s more, Lennox-Gastaut syndrome is a dangerous condition due to the frequent falls, injuries and cognitive (thinking) impairment that can impact the child’s quality of life.


In 20 to 30 percent of cases, there is no known cause of this condition. Some of the known causes of Lennox-Gastaut syndrome include:

  • Brain injury associated with pregnancy or birth, such as asphyxia, low birth weight or prematurity
  • Developmental malformations of the brain
  • Certain metabolic conditions
  • Severe brain infections, such as encephalitis, meningitis or rubella


The signs and symptoms of Lennox-Gastaut syndrome include:

  • Mood instability
  • Personality disturbances
  • Poor social skills and attention seeking behavior
  • Seizures

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