Pediatric Yunis-Varon Syndrome

Pediatric Yunis-Varon Syndrome



Yunis-Varon syndrome is a very rare condition that causes a variety of complications in systems throughout the body.

Expanded overview

Yunis-Varon syndrome is a rare, congenital (present at birth) condition that can affect the skeletal system, nervous system, hair and teeth. Many children with this condition have characteristic facial features or abnormalities of fingers and toes. In most cases, babies who are born with this condition experience breathing and/or feeding challenges.


Yunis-Varon syndrome is passed down in families (hereditary).


Signs and symptoms of Yunis-Varon syndrome include:

  • Abnormalities of fingers and toes (such as missing or underdeveloped thumbs, toes, or pinky fingers)
  • Abnormalities of the ears
  • Anteverted nares (upturned nostrils)
  • Developmental delays
  • Eyes that appear large or bulging
  • Failure to thrive (child who doesn’t grow or gain weight at the expected rate for their age)
  • Heart problems (including cardiomyopathy or congenital heart conditions 
  • Intellectual problems
  • Microcephaly (disproportionately small head)
  • Micrognathia (small jaw that can cause problems with eating and breathing)
  • Pelvic dysplasia (deformity of the pelvis)

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