Pediatric Dubin-Johnson Syndrome

Pediatric Dubin-Johnson Syndrome



Dubin-Johnson syndrome causes jaundice, which is a yellow tint to the skin and whites of the eyes.

Expanded overview

Dubin-Johnson syndrome is when someone older than a newborn develops jaundice (a yellow caste of the skin and whites of the eyes). Jaundice is a fairly common condition that affects otherwise healthy newborn babies. However, Dubin-Johnson syndrome usually appears in adolescence (12-17 years of age*) or early adulthood.

Dubin-Johnson syndrome seems to most frequently affect Jewish Iranian and Moroccan people living in Israel, as well as Japanese people. However, it can affect people of any ethnic background.


A gene mutation that is hereditary (passed down in families) causes Dubin-Johnson syndrome.


Signs and symptoms of Dubin-Johnson syndrome may include:

  • Jaundice 
  • Muscle weakness
  • Nausea
  • Pain in the upper abdomen
  • Vomiting

*Age of adolescence as defined by the Centers for Disease Control (CDC).

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