Intrahepatic cholestasis is a problem that affects the release of bile from the liver and can eventually lead to liver disease.
Bile is a liquid produced in the liver that helps remove toxins from the body. It also helps break down the fat in food so it can be processed by the intestines. Any condition that completely blocks the flow of bile from the liver or causes the bile flow to be slower than normal is called cholestasis. Intrahepatic cholestasis means that the cause of the problem started inside the liver.
If your child has intrahepatic cholestasis, three things happen:
Eventually, intrahepatic cholestasis can lead to liver disease.
Babies with intrahepatic cholestasis will show symptoms within two weeks of birth, including:
Intrahepatic cholestasis is caused by genetic defects that may lead to:
American Board of Pediatrics(Pediatric Transplant Hepatology),
American Board of Pediatrics,
American Board of Pediatrics/Gastroenterology