Pediatric Li-Fraumeni Syndrome (LFS)

Pediatric Li-Fraumeni Syndrome (LFS)



Li-Fraumeni syndrome (LFS) is a condition that runs in families, causing high rates of cancer and cancer diagnosis at a young age.

Expanded overview

Li-Fraumeni syndrome (LFS) is a hereditary (runs in families) condition in which several people across multiple generations develop various types of cancer, and they are typically diagnosed at a young age (under 30).

A person may be diagnosed with LFS when all of the following are true:

  • Develops a sarcoma (rare cancer that grows in connective tissue) before age 45
  • Has a first-degree relative (parent, sibling or child) who is diagnosed with any cancer before age 45
  • Has a first- or second-degree (grandparent, aunt, uncle, niece, nephew or grandchild) who is diagnosed with any cancer before age 45 or with a sarcoma at any age

The most common types of cancers found in families with LFS are:

  • Acute leukemia
  • Adrenal cortical tumors
  • Brain cancer
  • Breast cancer
  • Osteosarcoma (bone cancer)
  • Soft-tissue sarcoma


LFS is caused by a gene mutation that is hereditary (passed down within families).


Since LFS is a condition that increases the chance of cancer, children with this conditions should watch for signs of cancer, such as:

  • Frequent headaches or changes in vision
  • Loss of appetite or unexplained weight loss
  • Lumps or swelling of the skin
  • Unexplained aches and pains

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