Pediatric Li-Fraumeni Syndrome (LFS)
Li-Fraumeni syndrome (LFS) is a condition that runs in families, causing high rates of cancer and cancer diagnosis at a young age.
Li-Fraumeni syndrome (LFS) is a hereditary (runs in families) condition in which several people across multiple generations develop various types of cancer, and they are typically diagnosed at a young age (under 30).
A person may be diagnosed with LFS when all of the following are true:
- Develops a sarcoma (rare cancer that grows in connective tissue) before age 45
- Has a first-degree relative (parent, sibling or child) who is diagnosed with any cancer before age 45
- Has a first- or second-degree (grandparent, aunt, uncle, niece, nephew or grandchild) who is diagnosed with any cancer before age 45 or with a sarcoma at any age
The most common types of cancers found in families with LFS are:
- Acute leukemia
- Adrenal cortical tumors
- Brain cancer
- Breast cancer
- Osteosarcoma (bone cancer)
- Soft-tissue sarcoma
LFS is caused by a gene mutation that is hereditary (passed down within families).
Since LFS is a condition that increases the chance of cancer, children with this conditions should watch for signs of cancer, such as:
- Frequent headaches or changes in vision
- Loss of appetite or unexplained weight loss
- Lumps or swelling of the skin
- Unexplained aches and pains