Medullary thyroid cancer (MTC) is a type of thyroid cancer that originates in the parafollicular cells, which are known as “C” cells because they secrete the hormone calcitonin.
Risk factors for MTC may include:
There are two types of MTC:
Inherited MTC runs in families.
Sporadic MTC does not run in families.
There are several methods that are used for diagnosing MTC. Your child’s doctor may use a combination of these methods:
The exact cause of MTC is unknown. As with all types of cancers, it is caused by the growth of abnormal cells that multiply rapidly, forming what is known as a tumor.
The extent of surgical and medical treatment will depend on the extent of your child’s disease.
Initial treatment consists of surgical excision of the thyroid gland. Medullary thyroid carcinoma can spread through the body’s lymphatic system to lymph nodes in the neck adjacent to the thyroid gland and beyond, and surgical removal of these lymph nodes may also be required. In more advanced cases it may spread to the lungs.
Medullary thyroid cancer is not particularly sensitive to radioactive iodine ablation or chemotherapy, so surgical resection is the mainstay of treatment. Once surgical treatment is complete, in some cases radiation or other interventions may be required to treat extensive or residual disease.
American Board of Pediatrics/Endocrinology