Pediatric Extramedullary Hematopoiesis

Pediatric Extramedullary Hematopoiesis

Pediatric Extramedullary Hematopoiesis

Extramedullary hematopoiesis occurs when certain blood cells form outside of the medulla (bone marrow).

What is Pediatric Extramedullary Hematopoiesis?

In extramedullary hematopoiesis, a type of blood cell that normally only exists in the medulla of the bone (bone marrow) forms in other areas of the body. Extramedullary hematopoiesis typically forms as a mass or pseudotumor. The most common areas for this are the spleen or liver, but it can also occur in the skin, lungs, kidneys or other organs.

What are the different types of Pediatric Extramedullary Hematopoiesis?

There are two main types of extramedullary hematopoiesis:

Pathologic extramedullary hematopoiesis

Pathologic extramedullary hematopoiesis – occurs due to an abnormal reaction of the body’s immune system

Physiologic extramedullary hematopoiesis

Physiologic extramedullary hematopoiesis – occurs during fetal development

What are the signs and symptoms of Pediatric Extramedullary Hematopoiesis?

  • Nasal polyps
  • Nodules on the skin that often have a bluish tint

What are the causes of Pediatric Extramedullary Hematopoiesis?

This condition can occur during fetal development (physiologic), or it can be caused as a reaction of the body’s immune system (pathologic) in one of the following situations:

  • Bone marrow that is no longer functional
  • Infection in the bone marrow
  • Infection or inflammation in an organ