Zoe Rebecca O'Connor, MD $$

Pediatric Hematologist/Oncologist

Instructor at UT Southwestern Medical Center

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UT Southwestern Pediatric Group

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Zoe Rebecca O'Connor, M.D., is a hematologist and oncologist at Children's Health℠ and a faculty instructor in the Department of Pediatrics at UT Southwestern. She specializes in caring for children with cancer and blood disorders, including leukemia, lymphoma, other lymphoproliferative disorders and benign hematology.

The patients and families I get to work with are extremely brave, and I am able to build close bonds with them.
Dr. O'Connor

Dr. O’Connor earned her medical degree from the University of Texas Health Science Center at Houston. She completed her residency in pediatrics at Nicklaus Children’s Hospital and a hematology/oncology fellowship at the University of Texas Southwestern. 

“The patients and families I get to work with are extremely brave, and I am able to build close bonds with them. I enjoy the challenges involved in the evolving landscape of cancer treatment,” Dr. O’Connor says. 

In addition to treating patients, Dr. O’Connor conducts cancer research in immunotherapy (treatment that uses the body’s own immune system to treat cancer). This research involves how the gut microbiome in children with leukemia influences how they respond to a type of immunotherapy called chimeric antigen receptor (CAR) T-cell therapy.

Education and Training

Medical School
University of Texas Health Science Center at Houston (2017)
Nicklaus Children's Hospital (2020), Pediatrics
UT Southwestern - Childrens Medical Center (2023), Pediatric Hematology/Oncology


Benign Hematology

  • Research Interests

    • Leukemia
    • Lymphoma
    • Immunotherapy
    • Gut microbiome
    • Pediatric cancer
  • Publications

    • Anastasio N.C., Xia,Y., O’Connor Z., Johnson K.M.,; Differential Role of N-Methyl-D-Aspartate Receptor Subunits 2A and 2B in Mediating Phencyclidine-Induced Perinatal. Neuronal Apoptosis and Behavioral Deficits. Neuroscience 2009, 163, 1181-1191. 
    • Sexual Abuse and Assault in British Medical Journal Best Practice (contributor). https://bestpractice.bmj.com/topics/en-us/696
  • Professional Activities

    • American Academy of Pediatrics (AAP) Member (2017-2020)
    • American Society of Pediatric Hematology and Oncology Member (2020-present)
    • Children's Oncology Group Member (2021-present)
    • Society of Immunotherapy and Cancer Member (2022-2023)
  • Awards and Honors

    • College Scholar - The University of Texas as Austin (2011)
    • Allpha Lambda Delta and Phi Eta Sigma Honor Society Member - The University of Texas at Austin Chapter (2010-2013)

Where I Provide Care: