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The physicians in our directory are members of a Children’s Health hospital medical staff or are credentialed by Children’s Health for managed care participation. Some physicians are employed by Children’s Health, some are employed elsewhere, and some maintain an independent medical practice. There is no fee for being listed in our directory. The physicians populating your search results are selected based on the criteria that you provide and are then listed alphabetically. If a physician is no longer on a Children’s Health medical staff or participating in a Children’s Health managed care agreement, he/she would not be eligible to be listed in our directory.

James William Harbour, MD $$

Pediatric Ophthalmologist

Professor and Chair at UT Southwestern Medical Center

Languages Spoken:


UT Southwestern Pediatric Group

Education and Training

Medical School
Johns Hopkins University School of Medicine (1990)
Greater Baltimore Medical Ctr (1991), Internal Medicine
Wills Eye Residency Program at Jefferson (1994), Ophthalmology
University of California San Francisco Med Ctr (1996), Oncology
University of Miami School of Medicine (1995), Vitreoretinal Diseases
Board Certification
American Board of Ophthalmology


  • Pediatric Ocular Oncology
  • Vitreoretinal Diseases


  • Fine needle biopsy
  • Laser treatment
  • Brachytherapy of ocular tumors
  • Genetic prognostic testing for uveal melanoma

Departments and Programs

  • Research Interests

    • Ocular Oncology
    • Retinoblastoma
    • Uveal Melanoma
  • Publications

    • PRAME induces genomic instability in uveal melanoma. Harbour JW, Kurtenbach S, Sanchez M, Kuznetsoff J, Rodriguez D, Weich N, Dollar J, Cruz A, Kurtenbach S, Field M, Decatur C, Sorouri M, Lai F, Shiekhattar R, Pelaez D, Correa Z, Verdun R, Research square 2023 Apr
    • Advances in the clinical management of uveal melanoma. Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S, Nature reviews. Clinical oncology 2023 Feb 20 2 99-115
    • Pseudoangiomatous retinal gliosis (PARG) treated with iodine plaque in patient with chronic retinal detachment. Marquez MA, Fortun J, Iyer P, Harbour JW, Haddock LJ, American journal of ophthalmology case reports 2022 Sep 27 101614
    • Clinical characteristics and postoperative complications as predictors of radiation toxicity after treatment with I125 Eye Plaque Brachytherapy for Uveal Melanomas. Peters V, Gurayah A, Jin W, Kwon D, Zhao W, Patel NV, Markoe A, Correa Z, Studenski MT, Harbour JW, Samuels SE, Brachytherapy 2022 Sep
    • The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries. The Lancet. Global health 2022 08 10 8 e1128-e1140
    • RB1 loss triggers dependence on ESRRG in retinoblastoma. Field MG, Kuznetsoff JN, Zhang MG, Dollar JJ, Durante MA, Sayegh Y, Decatur CL, Kurtenbach S, Pelaez D, Harbour JW, Science advances 2022 Aug 8 33 eabm8466
    • BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in Class 2 Uveal Melanomas. Kaler CJ, Dollar JJ, Cruz AM, Kuznetsoff JN, Sanchez MI, Decatur CL, Licht JD, Smalley KSM, Correa ZM, Kurtenbach S, Harbour JW, Cancers 2022 Jul 14 15
    • Dissecting the Interplay Between Genetic Ancestry and Neighborhood Socioeconomic Status on Triple Negative Breast Cancer. Goel N, Yadegarynia S, Kwon D, Kesmodel SB, Harbour JW, Kobetz E, Merchant N, Rodriguez DA, Annals of surgery 2022 Jun
    • Hematologic Complications Associated With Intra-arterial Chemotherapy for Retinoblastoma Treatment: A Single Institution Experience. Sanati-Mehrizy A, Ghosh T, Peterson E, Starke RM, Harbour JW, Corrales-Medina FF, Journal of pediatric hematology/oncology 2022 May 44 4 181-185
    • Multi-omics profiling shows BAP1 loss is associated with upregulated cell adhesion molecules in uveal melanoma. Baqai U, Purwin TJ, Bechtel N, Chua V, Han A, Hartsough EJ, Kuznetsoff JN, Harbour JW, Aplin AE, Molecular cancer research : MCR 2022 Apr
    • HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma. Sriramareddy SN, Faião-Flores F, Emmons MF, Saha B, Chellappan S, Wyatt C, Smalley I, Licht JD, Durante MA, Harbour JW, Smalley KSM, Cancer gene therapy 2022 Mar
    • Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma. Han A, Chua V, Baqai U, Purwin TJ, Bechtel N, Hunter E, Tiago M, Seifert E, Speicher DW, Schug ZT, Harbour JW, Aplin AE, Oncogene 2022 Jan
    • Analytical Validation and Performance of a 7-Gene Next-Generation Sequencing Panel in Uveal Melanoma. Alsina KM, Sholl LM, Covington KR, Arnal SM, Durante MA, Decatur CL, Stone JF, Oelschlager KM, Harbour JW, Monzon FA, Cook RW, Borman S, Ocular oncology and pathology 2021 Dec 7 6 428-436
    • Functional impact of titin (TTN) mutations in ocular surface squamous neoplasia. Djulbegovic MB, Uversky VN, Karp CL, Harbour JW, International journal of biological macromolecules 2021 Nov
    • Waking Up With Cloudy Vision. Khine KT, Clark WM, Harbour JW, JAMA ophthalmology 2021 Oct
    • Structural Protein Analysis of Driver Gene Mutations in Conjunctival Melanoma. Djulbegovic MB, Uversky VN, Harbour JW, Galor A, Karp CL, Genes 2021 Oct 12 10
    • The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma. Chua V, Han A, Bechtel N, Purwin TJ, Hunter E, Liao C, Harbour JW, Aplin AE, Pigment cell & melanoma research 2021 Aug
    • Multiregional genetic evolution of metastatic uveal melanoma. Rodriguez DA, Yang J, Durante MA, Shoushtari AN, Moschos SJ, Wrzeszczynski KO, Harbour JW, Carvajal RD, NPJ Genom Med 2021 Aug 6 1 70
    • Impact of Genetic Ancestry on Prognostic Biomarkers in Uveal Melanoma. Rodriguez DA, Sanchez MI, Decatur CL, Correa ZM, Martin ER, Harbour JW, Cancers (Basel) 2020 Oct 12 11
    • Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer. Carbone M, Harbour JW, Brugarolas J, Bononi A, Pagano I, Dey A, Krausz T, Pass HI, Yang H, Gaudino G, Cancer Discov 2020 08 10 8 1103-1120
    • Single-cell analysis reveals new evolutionary complexity in uveal melanoma. Durante MA, Rodriguez DA, Kurtenbach S, Kuznetsov JN, Sanchez MI, Decatur CL, Snyder H, Feun LG, Livingstone AS, Harbour JW, Nat Commun 2020 01 11 1 496
  • Professional Activities

    • American Academy of Ophthalmology
    • American Association for Cancer Research
    • American Association of Ophthalmic Oncologists and Pathologists
    • American Ophthalmological Society
    • American Society of Retina Specialists
    • Association of American Physicians
    • Association for Research in Vision and Ophthalmology
    • Children’s Oncology Group
    • Collaborative Ocular Oncology Group (Founder)
    • International Society of Ocular Oncology
    • J. Donald M. Gass Society
    • Macula Society
    • Retina Society
    • Society of Heed Fellows
    • Society for Melanoma Research
  • Awards and Honors

    • Alcon Research Institute Award 2016
    • Retina Research Foundation/Kayser Global Award 2015, Pan-American Association of Ophthalmology
    • Silver Fellow 2014, Association for Research in Vision and Ophthalmology
    • Senior Scientific Investigator 2014, Research to Prevent Blindness, Inc.
    • Paul Henkind Memorial Award and Lecture 2014, Macula Society
    • Honor Award 2013, American Society of Retina Specialists
    • Shaler Richardson, MD Service to Medicine Award 2013, Florida Society of Ophthalmology
    • Senior Achievement Award 2012, American Academy of Ophthalmology
    • Research Award 2011, Ocular Melanoma Foundation
    • Rosenthal Award 2008, Macula Society
    • Cogan Award 2005, Association for Research in Vision and Ophthalmology
    • Achievement Award 2003, American Academy of Ophthalmology
    • Physician-Scientist Award 2002, Research to Prevent Blindness, Inc.
    • Heed-Knapp Ophthalmic Fellowship 1995-1996, University of California, San Francisco
    • Heed Ophthalmic Foundation Fellowship 1994-1995, Bascom Palmer Eye Institute

Where I Provide Care: