$$ Juan Manuel Pascual, MD Assistant Professor at UT Southwestern Medical Center


UTSW Physician Practicing at Children's Health

Languages Spoken: English,


Juan Pascual, M.D., Ph.D., is a neurologist at Children’s Health who specializes in genetic and metabolic diseases of the nervous and neuromuscular systems.

Dr. Pascual received his medical degree from the Universidad de Granada in Spain and his Ph.D. in molecular physiology and biophysics from Baylor College of Medicine in Houston. He also received residency training in pediatrics at Washington University School of Medicine/St. Louis Children’s Hospital and in neurology and pediatric neurology at the Neurological Institute of New York/Columbia University Medical Center.

As one of few actively practicing pediatric neurologists in the nation who is also a laboratory scientist, Dr. Pascual is interested in the molecular mechanisms that cause inherited metabolic and excitability disorders using electrophysiology and nuclear magnetic resonance (MRI) both in human subjects and in models of human diseases.

His laboratory is located in the newest biomedical research building (NL) at UT Southwestern and is an integral part of the Department of Neurology and Neurotherapeutics. The laboratory is home to scientists from very broad backgrounds and levels of training and expertise who have joined efforts to endow both pediatric neurology and human developmental neuroscience with a strong scientific basis.

As a clinician, Dr. Pascual specializes in genetic and metabolic diseases of the nervous and neuromuscular systems of infants, children and adults, with a particular emphasis on complex diagnostic problems, second opinions for patients visiting from the rest of the U.S. and abroad, and in clinical trials.

Dr. Pascual received certification in neurology with Special Qualification in child neurology from the American Board of Psychiatry and Neurology. He has special clinical research expertise in rare diseases, glucose metabolism, mitochondrial, degenerative and multi-organ disorders. 

Education and Training

Education and Training

Medical School

Universidad de Granada (1990)


Washington University School of Medicine (1999), Pediatrics


Columbia Univ College of Phys & Surgeons (2002), Pediatric Neurology

Graduate School

Baylor College of Medicine (1995)
Research & Publications

Research & Publications

Research Interests

  • 2-hit, multiple-gene and explanatory validity of complex causation models
  • Brain metabolism
  • Clinical trials for neurological and genetic disorders
  • Complex, rare and undiagnosed diseases
  • Final common pathways shared by diseases of neural development
  • Functional brain imaging
  • Human brain development
  • Mitochondrial disorders
  • Neural excitability: synaptic transmission
  • Neurodegenerative diseases of children
  • Neurogenetics
  • Sentience, autonomy and sources of truth
  • Whole exome and genome analyses in neurological disorders

Selected Publications

Professional Activities

Professional Activities

Professional Associations and Affiliations

  • Children's Medical Center Dallas (2007)
  • Parkland Memorial Hospital (2007)
  • UT Southwestern Medical Center Hospitals and Clinics (2007)

Awards & Honors

Awards & Honors

  • 100% Patient satisfaction - Division of Pediatric Neurology, Children's Medical Center Dallas (2013)
  • Elected full member - Académie Européenne des Sciences, des Arts et des Lettres (2013)
  • Research Mentor Award - Children's Medical Center Dallas (2012)
  • Elected corresponding member - Académie Européenne des Sciences, des Arts et des Lettres (2010)
  • Miembro correspondiente - Real Academia de Bellas Artes de San Telmo (2010)
  • Young Investigator Award - Neurobiology of Disease in Children (2009)
  • Miembro correspondiente - Real Academia Española (2004)
  • Miembro de número - Academia Norteamericana de la Lengua Española (2004)