Daniel Charles Bowers, MD $$ Professor Scholar at UT Southwestern Medical Center
UTSW Physician Practicing at Children's Health
Daniel Bowers, M.D., is the medical director of pediatric neuro-oncology at Children’s Health℠. He is also a professor of pediatrics and neurological surgery at UT Southwestern Medical Center.
Dr. Bowers earned his medical degree at UT Southwestern. He then completed his residency in general pediatrics at UT Southwestern and performed his fellowship in pediatric hematology and oncology at the Johns Hopkins University School of Medicine.
Dr. Bowers is a full member of the Children’s Oncology Group and serves on the central nervous system tumors committee, where his role is to develop new treatments for low-grade gliomas in children. He soon will be leading a national clinical trial for children with recurrent low-grade gliomas.
Dr. Bowers cares for children with brain tumors along with other members of the pediatric brain tumor multidisciplinary team, including pediatric neurosurgeons, radiation oncologists, pediatric neurologists, neuro-radiologists and neuro-pathologists.
He strongly believes in the care his team provides. “We offer the most advanced treatment that can be found anywhere in the world for a child with a brain tumor,” says Dr. Bowers. “Our outstanding group of doctors is unmatched. You can get it all right here.”
In addition to his clinical care of children with brain tumors, Dr. Bowers leads the After the Cancer Experience program at Children’s Medical Center, a childhood cancer survivorship program that monitors survivors of childhood cancer for long-term effects they may have from their cancer treatment or the cancer itself.
"As more children survive their cancer diagnosis, we know that about two-thirds of them have some long-term complication and about one-third will have what is considered a severe or life-threatening complication," Dr. Bowers says. “When we monitor these children as they grow, we can intervene if something starts to change or go wrong and help them through it.”
Dr. Bowers is well known nationally for his understanding of the long-term side effects seen among childhood brain tumor survivors. He has been recognized by D Magazine as a Best Doctor in the category of Best Pediatric Specialist: Oncology/Hematology and as a favorite oncology professional by CureSearch for Children’s Cancer.
Dr. Bowers serves on the advisory committee on childhood cancers for the Cancer Prevention and Research Institute of Texas and as a member of the board of directors of the Clayton Dabney Foundation. He also is a member of the American Society of Clinical Oncology, the Society for Neuro-Oncology, the American Society of Pediatric Hematology/Oncology and the Society for Pediatric Research.
Education and Training
Medical SchoolUniversity of Texas Southwestern Medical Center (1993)
InternshipChildren's Medical Center Dallas (1994), Pediatrics
ResidencyChildren's Medical Center Dallas (1996), Pediatrics
FellowshipJohn Hopkins Hospital (1999), Pediatric Hematology/Oncology
Research & Publications
- Development of novel chemotherapy regimens for children with recurrent cancer
- Evaluation of quality of life and late effects of childhood cancer survivors
- New therapies for childhood brain tumors
- Radiation, Atherosclerotic Risk Factors and Stroke Risk in Young Adult Survivors of Pediatric Cancer: Report from the Childhood Cancer Survivor Study. Mueller S, Fullerton HJ, Stratton K, Leisenring W, Weathers RE, Stovall M, Armstrong GT, Goldsby RE, Packer RJ, Sklar CA, Bowers DC, Robison LL, Krull KR. International Journal of Radiation Oncology, Biology, Physics, 2013; 86:649-55.
- Genomic Analysis of Diffuse Pediatric Low-Grade Gliomas Identifies Recurrent, Oncogenic MYBL1-Truncating Rearrangements. Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence M, Bergthold G, Brastianos PL, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho Y-J, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Ashley Hill D, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110:8188-93.
- Subsequent Neoplasms of the Central Nervous System among Survivors of Childhood Cancer: A Systematic Review: A Report from the Second Malignant Neoplasm Task Force of the Survivorship and Outcomes Committee of the Children’s Oncology Group. Bowers DC, Nathan PC, Constine L, Woodman C, Bhatia S, Keller K, Bashore L. Lancet Oncology, 2013; 14:e321–28.
- Common Pediatric Cerebellar Tumors: Correlation between Cell Densities and Apparent Diffusion Coefficient Metrics. Koral K, Mathis D, Gimi B, Gargan L, Weprin B, Bowers DC, Margraf L. Radiology 2013; 268(2):532-537
- Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma. Fontebasso AM, Papillon-Cavanagh S, Schwartzentruber J, Nikbakht H, Gerges N, Fiset PO, Bechet D, Faury D, De Jay N, Ramkissoon LA, Corcoran A, Jones DT, Sturm D, Johann P, Tomita T, Goldman S, Nagib M, Bendel A, Goumnerova L, Bowers DC, Leonard JR, Rubin JB, Alden T, Browd S, Geyer JR, Leary S, Jallo G, Cohen K, Gupta N, Prados MD, Carret AS, Ellezam B, Crevier L, Klekner A, Bognar L, Hauser P, Garami M, Myseros J, Dong Z, Siegel PM, Malkin H, Ligon AH, Albrecht S, Pfister SM, Ligon KL, Majewski J, Jabado N, Kieran MW. Nature Genetics. 2014; 46(5): 462-6.
- Pleomorphic Xanthoastrocytoma of Childhood: MRI and Diffusion MRI Features. Moore W, Mathis D, Gargan L, Bowers DC, Klesse L Margraf L, Koral K. American Journal of Neuroradiology, 2014.
- Applicability of Apparent Diffusion Coefficient Ratios in Preoperative Diagnosis of Common Pediatric Cerebellar Tumors across Two Institutions. Koral K, Alford R, Choudhury N, Mossa-Basha M, Gargan L, Gimi B, Gao A, Zhang S, Bowers DC, Koral KM, Izbudak I. Neuroradiology, 2014.56(9):781-8.
- Mutations in ACVR1, FGFR1, NF1, and TP53 Associate with Tumor Location in Histone H3 K27M Midline Pediatric High-Grade Astrocytoma, Fontebasso AM, Papillon-Cavanagh S, Schwartzentruber J, Nikhbakht H, Gerges N, Fiset PO, Bechet D, Faury D, De Jay N, Jones DTW, Sturm D, Johann P, Tomita T, Goldman S, Nagib M, Bendel A, Goumnerova L, Bowers DC, Leonard JR, Rubin JB, Alden T, Browd S, Geyer JR, Jallo G, Cohen K, Gupta N, Prados MD, Carret AS, Ellezam B, Klekner A, Bognar L, Hauser P, Garami M, Myseros J, Ligon A, Albrecht S, Pfister SM, Ligon SL, Majewski J, Jabado N, Kieran MW. Nature Genetics. 2014 46(5):462-466.
- Effect of Motivation on Academic Fluency Performance in Survivors of Pediatric Medulloblastoma. Holland, AA, Hughes C, Harder L, Silver C, Bowers DC, Stavinoha P. Child Neuropsychology - A Journal on Normal and Abnormal Development in Childhood and Adolescence. 2015 Mar 31:1-17.
- Hepatocyte growth factor activates the Akt pathway and inhibits chemotherapy and radiation induced cell death in human glioma cells, Bowers DC, Fan S, Willimas JA, Rosen EM, Laterra J Cancer Research 2000 60 (15) 4277-4283
- Predictors of tumor progression among children with gangliogliomas, El-Khashab MA, Gargan L, Margraf L, Koral K, Nejat F, Weprin B, Swift D. Bowers, DC Journal of Neurosurgery - Pediatrics 2009 3 461-466
- High-risk populations identified in Childhood Cancer Survivor Study investigations: implications for risk-based surveillance., Hudson MM, Mulrooney DA, Bowers DC, Sklar CA, Green DM, Donaldson SS, Oeffinger KC, Neglia JP, Meadows AT, Robison LL Journal of Clinical Oncology 2009 27 2405-2414
- Intermediate grade meningeal melanocytoma of cervical spine., El-Khashab MA, Koral K, Bowers DC, Johnson-Welch S, Swift D, Nejat F Child’s Nervous System 2009 25 407-410
- A single-arm, open label multi-institutional phase II study of multi-agent intrathecal and systemic chemotherapy with radiation therapy for children with newly-diagnosed central nervous system atypical teratoid/rhabdoid tumor, Chi SN, Zimmerman MA, Yao X, Fletcher W, Cohen K, Burger P, Biegel J, Rorke-Adams LF, Fisher M, Janss A, Mazewski C, Goldman S, Manley P, Bowers DC, Bendel A, Rubin J, Turner CD, Marcus K, Goumnerova L, Roberts C, Ullrich N, Chordas C, Kieran MW Journal of Clinical Oncology 2009 27 385-389
- The impact of site of tumor recurrence upon survival for children with recurrent or progressive medulloblastoma, Bowers DC, Gargan L, Weprin BE, Mulne AF, Elterman RD, Munoz L, Giller CA, Winick NJ Journal of Neurosurgery - Pediatrics 2007 107 5-10
Professional Associations and Affiliations
- American Society of Clinical Oncology
- American Society of Pediatric Hematology/Oncology
- Children’s Oncology Group
- Society for Neuro-Oncology
- Society for Pediatric Research
Awards & Honors
- Elected to the Society for Pediatric Research (2006)
- Outstanding Graduate in the College of Science (1989)