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Critical Care Services
At Children's Medical CenterPublications
The following are publications by the faculty and fellows of Critical Care Services. Choose a year to begin.
2004
Barton, P, Kalil, A., Levin, M., Goldstein, B., Jefferson, L., Brilli, R., Takano, J., Martin, L., Quint, P., Yeh, T., Dalton, H., Gessouron, R.M., Brown, K.E., Betts, H., Macias, W., Small, D.S., Wyss, V.L., Bates, B.M., Utterback, B.G., Giroir, B. Safety, Pharmacolkinetics, and Pharmacodynamics of Drotrecogin Alfa (Activated) in Children with Severe Sepsis. Pediatrics, 2004. January Vol.113.
Salman, H., Ghosh, P., and Kernie, S.G. Subventricular zone neural stem cells remodel the brain following traumatic injury in adult mice. Journal of Neurotrauma. 2004, Vol 21 (3). 283-92.
Rubenstein, J.L.R. and Kernie, S.G. Overview of Brain Development. Oeurobiology of Mental Illness. Second Edition. 2004. (book chapter)
2003
White J, Carson DL, Thompson M, Maass DL, Saunders B, Giroir B, Horton JW. Molecular and pharmacological approaches to inhibiting nitric oxide after burn trauma. Am J Physiol Heart Circ Physiol. 2003. Oct; Vol 285 (4): H1616-25.
Tortoriello TA, Friedman J, Fraser CF, McKenzie ED, Feltes TF, Mott AR. Mediastinitis in Pediatric Postoperative Cardiac Patients: A 15 Year Experience at a Single Institution. Annals of Thoracic Surgery. 2003, Nov. Vol 76(5):1655-60.
Tortoriello TA, Snyder CS, Smith EO, Fenrich AL, Friedman RA, Kertesz, NJ. Frequency of Recurrence Among Infants with Supraventricular Tachycardia and Comparison of Recurrence Rates Among those With and Without Preexcitation and Among those With and Without Response to Digoxin and/or Propranolol Therapy. American Journal of Cardiology. 2003 Nov 1 ; Vol 92 (9):1045-9.
B. Zingarelli, M. Sheehan, P. W. Hake, M. O' Connor, A. Denenberg, J. Cook. Perixosome proliferators activator receptor-? ligands, 15-deoxy-? 12, 14- prostaglandin J2 and ciglitizone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways. J Immunol. 2003, Dec. Vol 15;171 (12):6827-37.
Garner LB, Willis MS, Carlson DL, DiMaio JM, White MD, White DJ, Adams GA 4th, Horton JW, Giroir BP. Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor, Am J Physiol Heart Circ Physiol. 2003, Vol 285: H2500-H2509.
Carlson, D.L., White, D.J., Maass, D.L., Nguyen, R.C., Horton, J., Giroir, B., I B Overexpression in Cardiomyocytes Prevents NF- B Nuclear Translocation and Provides Cardioprotection in Trauma. Am. J. of Physiology, 2003, Vol 284:H804-H814.
Nicholson C.E., Gans B.M., Chang A.C., Pollack M.M., Blackman J., Giroir B.P., Wilson D, Zimmerman J.J., Whyte J., Dalton H.J., Carcillo J.A., Randolph A.G., Kochanek P.M. Pediatric Critical Care Medicine: Planning for our research future. Pediatric Critical Care Medicine. 2003, Vol 4 (2):196-202.
Thomas, J.A., Haudek, S.B., Koroglu, T. , Tsen, M.F., Bryant, D.D., White, D.J., Kusewitt, D.F., Horton, J., and Giroir, B. IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction. Am.J. of Physiol Heart Care Physiol. 2003, Vol 285:H597-606.
Ma, W., Shang-Feaster, G., Okada, P., Kernie, S.G. Elevated cerebrospinal fluid levels of glutamate in children with bacterial meningitis as a predictor of the development of seizures or other adverse outcomes. Pediatric Critical Care Medicine. 2003, Vol 4 (2). 170-75.
B. Zingarelli, M. Sheehan, H. R. Wong. Nuclear factor-KB as a therapeutic target in critical care medicine. Crit Care Med. 2003, Vol. 31, No. 1 (Suppl.)
M. Sheehan, H. R. Wong, P. W. Hake, B. Zingarelli. Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymycrobial sepsis. Crit Care Med. 2003, Vol. 31, No. 9.
Deng, C, CG Radu, A. Diab, R Hussain, MF Tsen, JS Cowdery, MA Racke, JA Thomas, "The IL-1 Receptor-associated Kinase-1 (IRAK1) regulates susceptibility to organ-specific autoimmunity," The Journal of Immunology. 2003, Vol 170 (6):2833-42.
White, J, JA Thomas, DL Maass, JW Horton, "The cardiac effects of burn trauma complicated by aspiration-pneumonia-induced sepsis," The American Journal of Physiology: Heart and Circulatory Physiology. 2003, Vol 825 (1): H47-58.
2002
Carlson, D.L., Lightfoot, E., Bryant, D., Haudek, S., Maass, D., Horton, J. and Giroir, B. Burn Plasma Mediates Cardiac Myocyte Apoptosis Via Endotoxin. Am. J. Phys., Heart Circ. Physiol. 2002, May; Vol 282 (5):H1907-14.
Mou, S., Haudek, S., Lequier, L., Pena, O., Leonard, S., Nikaidoh, H., Giroir, B., and Stromberg, D. Myocardial inflammatory activation in children with congenital heart disease. Critical Care Medicine. 2002, Vol 30:827-832.
Ma W., Lemler, M., Nikaidoh, H., Leonard, S., Shang-Feaster, G., Giroir, B., Stromberg, D. Usefulness of External Counterpulsation Early Postoperatively After the Fontan Procedure in Children. American Journal of Cardiology. 2002, Vol. 90. 1029-1031.
Yoder BA, Kirsch EA, Barth WH, Gordon MC. Changing Obstetric Practices Associated With Decreasing Incidence of Meconium Aspiration Syndrome. Obstet Gynecol. 2002, Vol 99:731-9.
Randolph AG, Wypij D, Venkataraman S, Hanson JH, Gedeit R, Meert K, Luckett PM, Lilley M, Thompson J, Cheifetz I, Hibberd P, Wetzel R, Cox P, Arnold P. Effect of Mechanical Ventilator Weaning Protocols on Respiratory Outcomes in Infants and Children: A Randomized Controlled Trial. JAMA. 2002, Vol 288:2561.
Gruchalla R, Gan V, Roy L, Bokovoy J, McDermott S, Lawrence G, Hynan LS, Luckett PM. Results of an Inner-City School-Bases Asthma and Allergy Screening Pilot Study: A Combined Approach Using Written Questionnaires and Step Testing. Annals of Allergy, Asthma and Immunology. 2002.
M. Sheehan, H. R. Wong, P. W. Hake, Vivek Malhotra, Michael O' Connor and B. Zingarelli. Parthenolide, an inhibitor of the nuclear factor-KB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Mol Pharmacol. 2002, Vol 61:953-63.
M. Sheehan, H. R. Wong, P. W. Hake, B. Zingarelli. Protective effects of isohelenin, an inhibitor of nuclear factor-KB, in endotoxic shock in rats. Journal of Endotoxin Research. 2002, Vol 8: 99-107. M. Sheehan, H. R. Wong. Yet another potential role for nitric oxide in the pathophysiology of septic shock. Crit Care Med. 2002, Vol. 30, No. 6
Buckingham S, Jafri HS, Bush AJ, Carubelli CM, Sheeran PW, Hardy RD, Ottolini MG, Ramilo O, Devincenzo JP. A Randomized, Double-Blind, Placebo-Controlled Trial of Dexamethasone in Severe Respiratory Syncytial Virus Infection: Effects on RSV Quantity and Clinical Outcome. Journal of Infectious Diseases. 2002, Vol 185: 1222-8.
Lemler MS, Scott WA, Leonard SR, Stromberg D, Ramaciotti C. Fenestration Improves Clinical Outcome of the Fontan Procedure: A Prospective Randomized Study. Circulation. 2002, Vol 105:207-212.
Thomas, JA, MF Tsen, J White, J Horton, "IRAK contributes to burn-induced myocardial contractile dysfunction," The American Journal of Physiology: Heart and Circulatory Physiology. 2002, Vol 283 (2):H829-36.
Thomas, JA, MF Tsen, J White, J Horton, "Toll-like receptor 4 inactivation and bactericidal permeability-increasing protein block burn-induced myocardial contractile dysfunction," The American Journal of Physiology: Heart and Circulatory Physiology. 2002, Vol 283 (4):H1645-55.
McMahon CJ, Feltes TF, Fraley JK, Bricker JT, Grifka RG, Tortoriello TA, Blake R, Bezold LI. Natural history of growth of secundum atrial septal defects and implications for transcatheter closure. Heart. 2002, Vol 87 (3):256-259.
Tortoriello TA, McMahon CJ, Blake Rebecca, Grifka RG, Bricker JT. Growth of an Atrial Septal Defect: Missing the Window for Transcatheter Closure. Pediatric Cardiology. 2002, Vol 23 (5):542-544.
Tortoriello TA, Vick GW, Chung T, Bezold LI, Vincent JA. Meandering Right Pulmonary Vein to the Left Atrium and Inferior Vena Cava: the First Case with Associated Anomalies. Texas Heart Institute Journal. 2002, Vol 29 (4): 319-323.
2001
Giroir, B. Bactericidal/permeability-increasing protein: clinical development and potential pediatric applications. Pediatric Infectious Disease. 2001 Sept. Vol 20 (9):885-887.
Vincent D, Tasian D, Stromberg D. Beyond the Mock Up - The Value of Temporary Occupancy and Evaluation. AIA Health Academy Journal. 2001, Oct. Vol. 4
Graciano, A.L.; Bryant, D.D.; White, D.J.; Horton, J.; Bowles, N.E.; and Giroir, B. Targeted disruption of ICAM-1, P-selection genes improves cardiac function and survival in TNF-a transgenic mice. 2001. Am J. Phys.; Heart Circ. Physiol, 280:H1464-71.
White, J.; Maass, D.; Giroir, B.; and Horton, J. Development of acute burn model in adult mice for studies for cardiac function and cardiomyocyte cellular function. 2001. Shock, 16:122-129.
Horton, J.; White, D.J.; Maass, D.; Hybki, D.P.; Haudek S.; and Giroir, B.
Antioxidant Vitamin Therapy Alters Burn Trauma Mediated Cardiac NF-KB
Activation and Cardiomyocyte Cytokine Secretion. 2001. J. Trauma, 50:397-408.
Haudek, S.B.; Spencer, E.; Bryant, D.D.; White, D.J.; Maass, D.; Horton, J.; Chen, Z.J.; and Giroir, B. Over-expression of cardiac IkBa prevents endotoxin-induced myocardial dysfunction. 2001. Am. J. Phys.; Heart Circ. Physiol, 280:H962-968.
Haudek, S.B.; Bryant D.D.; and Giroir, B. Differential regulation of myocardial NFkB following acute or chronic TNFa exposure. 2001. Journal of Molecular &Cellular Cardiology, 33:1263-1271.
Giroir, B.; Scannon, P.; and Levin, M. Bactericidal/Permeability - Increasing Protein (BPI) - Lessons Learned from the Phase III, Randomized, Clinical Trial of rBPI for Adjunctive Treatment of Children with Severe Meningococcemia. 2001. Critical Care Medicine, 29:S130-135.
Chan, E.L.; Haudek, S.B.; Giroir, B.; and Murphy, J.T. Human Coronary Endothelial Cell Activation by Endotoxin is Characterized by NF-kB Activation and TNF-a Synthesis. 2001. Shock, 16:349-354.
Giroir, B.; Stromberg, D. Myocardial Depression versus Myocardial Destruction: Integrating the Multiple Mechanisms of Myocardial Dysfunction During Sepsis. Critical Care Medicine, 2000; 28(8):3111-3112Vincent D, Tasian D, Stromberg D. Beyond the Mock Up - The Value of Temporary Occupancy and Evaluation. AIA Health Academy Journal, vol. 4, October 2001.
Giroir, B. and Cox, P. Current Concepts in Pediatric Critical Care - 2001. Society of Critical Care Medicine.
Kernie, S.G.; Erwin, T.M.; and Parada, L.F. Brain remodeling due to neuronal and astrocytic proliferation following controlled cortical injury in mice. The Journal of Neuroscience Research 2001. Nov: 66(3). 317-26.
2000
Thompson, M., Arteaga, G., Horton, J., Becker, L., White, D.J., Bryant, D., Maass, D. and Giroir, B. The role of increased intracellular calcium during endotoxin-induced cardiac dysfunction in guinea pigs. Pediatric Research. 2000, Vol 47:669-676.
Lequier, L.; Nikaidoh, H.; Leonard, S.R.; Bokovoy, J.L.; White, M.L.; Carroll, S.L.; Scannon, P.; and Giroir, B. Pre- and postoperative endotoxemia in children with congenital heart disease. 2000. Chest, 117:1706-1712.
Kirsch, E.; and Giroir, B. Improving the outcome of septic shock in children in the 21 century. 2000. Current Opinion in Infectious Diseases, 13:253-258.
Giroir, B. Meningococcemia as a model to test the hypothesis of anti-sepsis therapies. 2000. Critical Care Medicine, 28:S57-59.
Levin, M.; Quint, P.A.; Goldstein, B.; Barton, P.; Bradley, J.S.; Shemie, S.D.; Yeh T.; Kim, S.S.; Cafaro, D.P.; Scannon, P.; Giroir, B. Recombinant batericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. rBPI21 Meningococcal Sepsis Study Group. 2000. Lancet, 356:961-67.
Fineman, J.R.; Giroir, B. Current Concepts in Pediatric Critical Care - 2000. Society of Critical Care Medicine.
Kernie, S.G.; Leibl, D.J.; and Parado, L.F. BDNF regulates weight and locomotor activity in mice. EMBO Journal. 2000. Mar: 19 (6). 1290-1300.
Kernie, S.G. and Parada, L.F. The molecular basis for understanding the role of neurotrophins in human disease. Archives of Neurology. 2000. May: 57. 654-57.
Iannaccone, S.T.; Mills, J.; Harris, K.; Herman, J.; Schochet, P.; Luckett, P.M. Congenital Myasthenic Syndrome with bilateral diaphragm paralysis. Muscle & Nerve 23(7): 1129-32, 2000.
Graciano, A.L.; Barton, P.; Toro-Figueroa, L.O.; Morriss, F.C.; Sommerauer, J.F.; Luckett, P.M. The feasibility of asynchronous independent lung high frequency oscillatory ventilation in the management of acute hypoxemic respiratory failure: A case report. Critical Care Medicine 28(8): 3075-7, 2000.
Michelow, I.C.; McCracken, G.H.; Luckett, P.M.; Krisher, K. Abiotrophia sp. Brain Abscess in a Child with Down syndrome. J.Ped. Inf. Dis. 19(8): 760-763, 2000.
Doroshow, R.W.; Hodgman, J.E.; Pomerance, J.; Ross, J.R.; Michel, V.J.; Luckett, P.M.; Shaw, A. Treatment decisions for newborns at the threshold of viability: an ethical dilemma. Journal of Perinatology 20:379-383, 2000.
Biswas, A.; Scott, W.; Sommerauer, J.; Luckett, P.M. Heart rate variability after acute traumatic brain injury in children. Critical Care Medicine 28: 3907-3912, 2000.
Arnold, J.H.; Anas, N.G.; Luckett, P.M.; Cheifetz, I.M.; Reyes, G.; Newth, C.J.L.; Kocis, K.C.; Heidermann, S.M.; Hanson, J.H.; Brogan, T.V.; Bohn, D.J. High frequency oscillatory ventilation in pediatric respiratory failure: a multicenter experience. Critical Care Med 28:3913-3919, 2000.
Thomas, J.A. Toll genes and responsiveness to bacterial endotoxin (letter). The New England Journal of Medicine, 2000, 324:664.
Swantek, J.L.; Tsen, M.F.; Cobb, M.H.; Thomas, J.A. IRAK modulates host responsiveness to endotoxin. The Journal of Immunology, 2000, 164(8):4301-4306.
Felner, E.L.; Thompson, M.T.; Ratliff, A.F.; White, P.C.; Dickson, B.A. Time course of recovery of adrenal function in children treated for leukemia. Journal of Pediatrics 2000 137(1): 21-4.
Giroir B, Stromberg D. Myocardial Depression versus Myocardial Destruction: Integrating the Multiple Mechanisms of Myocardial Dysfunction During Sepsis. Critical Care Medicine. 2000, Vol 28 (8):3111-3112.
1999
Franco, F.; Thomas, G.; Giroir, B.; Bryant, D.; Bullock, C.; Chwialkowski, M.; Victor, R.; and Peshock, R. Magnetic resonance imaging and invasive evaluation of the development of heart failure in transgenic mice with myocardial expression of tumor necrosis factor alpha. 1999. Circulation, 99:448-454.
Murphy, J.; Giroir, B.; and Horton, J. Thermal injury alters myocardial sarcoplasmic reticulum calcium channel function. 1999. Journal of Surgical Research, 82:1-9.
Horton, J.; White, D.; Maass, D.; Sanders, B.; Thompson, M.; and Giroir, B. Calcium antagonists improve cardiac mechanical performance after thermal trauma. 1999. Journal of Surgical Research, 87:39-50.
Kirsch, E.A.; Yuhanna, I.S.; Chen, Z.; Sherman, T.S.; German, Z.; Shaul, P.W. Estrogen Stimulates Endothelial Nitric Oxide Synthase Activity in H441 Human Airway Epithelium. Am J Resp Cell Molec Biol. 1999; 20: 658-66.
Sheeran, P.W.; Jafri, H.; Johnson, C.; Saveedra, J.; Carrubeli, C.; Ramilo, O. Elevated cytokine concentrations in the nasopharyngeal and tracheal aspirates of children with respiratory syncytial virus disease. Ped Inf Dis J, 18:115-22, 1999.
Stromberg, D.; Pignatelli, R.; Ing, F.F. Does Ductal Occlusion with the Gianturco Coil Cause Left Pulmonary Artery and/or Descending Aortic Obstruction? American Journal of Cardiology, 1999; 83:1229-1235.
Akhtar, N.; Ni, J.; Stromberg, D.; Rosenthal, G.L.; Bowles, N.E.; Towbin, J.A. Trachael Aspirate as a Substrate for PCR Detection of Viral Genome in Childhood Pneumonia and Myocarditis. Circulation, 1999; 99:2011-2018.
Sorof, J.M.; Stromberg, D.; Brewer, E.D.; Feltes, T.F.; Fraser, C.D., Jr. Early Use of Peritoneal Dialysis After Surgical Repair of Congenital Heart Disease. Pediatric Nephrology, 1999; 13(8):641-645.
Thomas, J.A.; Allen, J.L.; Tsen, M.; Dubnicoff, T.; Danao, J.; Liao, X.C.; Cao, Z.; Wasserman, S.A. Impaired cytokine signaling in mice lacking the interleukin-1 receptor associated kinase. The Journal of Immunology, 1999, 163:978-984.